All-In Podcast
Industry veterans, degenerate gamblers & besties Chamath Palihapitiya, Jason Calacanis, David Sacks & David Friedberg cover all things economic, tech, political, social & poker.
Juan Carlos Izpisua Belmonte, Altos Labs | All-In Summit 2024
This episode introduces Altos Labs and their quest to reverse aging, akin to a modern search for the fountain of youth. We delve into their groundbreaking research using Yamanaka factors to reverse aging in mice, exploring potential impacts on age reversal and disease treatment. The discussion covers organ rejuvenation and eliminating unhealthy cells, cellular reprogramming, and how exercise influences gene expression. We also explore market opportunities for cellular reprogramming technologies, concluding with insights into Altos Labs' organizational structure, funding, and the balance between research and product development.
Key Points
- Yamanaka factor-based cell reprogramming methods hold the potential to significantly rejuvenate cells and delay or reverse aging-related diseases.
- Short pulses of the Yamanaka factors can alter chromatin structure to increase cellular resilience without erasing cell identity, thereby improving healthspan and lifespan in animal models.
- Exercise and certain lifestyle choices can mimic the beneficial effects of Yamanaka factors on gene expression, suggesting practical ways to enhance cellular health while awaiting further advancements in medical applications.
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Transcript
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